Abstract 442: Loss of Kiaa1462 , a Coronary Artery Disease Associated Gene, Decreases Atherosclerosis

Introduction: KIAA1462 is the only coding gene in a chromosome 10 genomic locus consistently associated with Coronary Artery Disease (CAD) in Genome Wide Association Studies. KIAA1462 has no recognizable functional domains and little homology to other protein families, but has been previously implicated in endothelial cell proliferation and angiogenesis. We used a murine knock out (KO) model to investigate the role of Kiaa1462 in the development...