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Long-Term Effects of Randomization to a Weight Loss Intervention in Older Adults: A Pilot Study

Published on Jan 2, 2019in Journal of nutrition in gerontology and geriatrics
· DOI :10.1080/21551197.2019.1572570
Denise K. Houston45
Estimated H-index: 45
(Wake Forest University),
Michael I. Miller98
Estimated H-index: 98
(Wake Forest University)
+ 5 AuthorsBarbara J. Nicklas62
Estimated H-index: 62
(Wake Forest University)
Abstract
AbstractRandomized, controlled trials (RCTs) show intentional weight loss improves body composition and physical function in older adults; however, the long-term benefits (and risks) are unknown. W...
  • References (47)
  • Citations (2)
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References47
Newest
#1Denise K. Houston (Wake Forest University)H-Index: 45
#2Rebecca H. Neiberg (Wake Forest University)H-Index: 22
Last. Stephen B. Kritchevsky (Wake Forest University)H-Index: 99
view all 44 authors...
Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods: Overweight and obese (body mass index ≥ 25 kg/m2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial e...
7 CitationsSource
#1Barbara J. Nicklas (Wake Forest University)H-Index: 62
#2Tina E. Brinkley (Wake Forest University)H-Index: 14
Last. Xiaoyan Leng (Wake Forest University)H-Index: 25
view all 7 authors...
BACKGROUND: Obesity compounds aging-related declines in cardiorespiratory fitness, with accompanying fatigue and disability. This study determined the effects of two different levels of caloric restriction (CR) during aerobic training on cardiorespiratory fitness, fatigue, physical function, and cardiometabolic risk. METHODS: The INFINITE study was a 20-week randomized trial in 180 older (65-79 years) men and women with obesity (body mass index = 30-45 kg/m2). Participants were randomly assigned...
2 CitationsSource
#1Kristen M. Beavers (Wake Forest University)H-Index: 16
#2Walter T. Ambrosius (Wake Forest University)H-Index: 44
Last. Anthony P. Marsh (Wake Forest University)H-Index: 22
view all 10 authors...
Objective To examine the long-term effects of exercise modality during weight loss on body composition and associations between body composition and physical function changes. Methods Two hundred forty-nine older adults (66.9 ± 4.7 years, 71% women, 32% African American, BMI: 34.4 ± 3.7 kg/m2) were randomized to weight loss (WL; n = 82), WL plus aerobic training (WL + AT; n = 86), or WL plus resistance training (WL + RT; n = 81) for 18 months. Dual-energy x-ray absorptiometry–acquired body compo...
7 CitationsSource
BackgroundObesity causes frailty in older adults; however, weight loss might accelerate age-related loss of muscle and bone mass and resultant sarcopenia and osteopenia. MethodsIn this clinical trial involving 160 obese older adults, we evaluated the effectiveness of several exercise modes in reversing frailty and preventing reduction in muscle and bone mass induced by weight loss. Participants were randomly assigned to a weight-management program plus one of three exercise programs — aerobic tr...
90 CitationsSource
#1W. Jack Rejeski (Wake Forest University)H-Index: 58
#2Walter T. AmbrosiusH-Index: 44
Last. Anthony P. Marsh (Wake Forest University)H-Index: 22
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Background: Among older, overweight, and obese adults with either cardiovascular disease or the metabolic syndrome, reduced mobility and loss of leg strength are important risk factors for morbidity, disability, and mortality. It is unclear whether community-based approaches to weight loss may be an effective solution to this public health challenge. Methods: An 18-month three-site, randomized controlled trial conducted by YMCA staff, with blinded assessors, enrolled 249 older, overweight, and o...
16 CitationsSource
#1Julie L. Locher (UAB: University of Alabama at Birmingham)H-Index: 38
#2TaShauna U. Goldsby (UAB: University of Alabama at Birmingham)H-Index: 6
Last. Jamy D. Ard (Wake Forest University)H-Index: 33
view all 6 authors...
Abstract The evidence regarding recommendations of calorie restriction as part of a comprehensive lifestyle intervention to promote weight loss in obese older adults has remained equivocal for more than a decade. The older adult population is the fastest growing segment of the US population and a greater proportion of them are entering old age obese. These older adults require treatments based on solid evidence. Therefore the purpose of this review is three-fold: 1) to provide a more current sta...
19 CitationsSource
#1Elizabeth Chmelo (Wake Forest University)H-Index: 9
#2D. P. Beavers (Wake Forest University)H-Index: 3
Last. Kristen M. Beavers (Wake Forest University)H-Index: 16
view all 6 authors...
Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults
5 CitationsSource
#1Kathryn N. Porter Starr (Duke University)H-Index: 7
#2Carl F. Pieper (Duke University)H-Index: 77
Last. Connie W. Bales (Duke University)H-Index: 34
view all 8 authors...
Background: Obesity is a significant cause of functional limitations in older adults; yet, concerns that weight reduction could diminish muscle along with fat mass have impeded progress toward an intervention. Meal-based enhancement of protein intake could protect function and/or lean mass but has not been studied during geriatric obesity reduction. Methods: In this 6-month randomized controlled trial, 67 obese (body mass index ≥30 kg/m 2 ) older (≥60 years) adults with a Short Physical Performa...
25 CitationsSource
#1Dalane W. Kitzman (Wake Forest University)H-Index: 80
#2Peter H. Brubaker (Wake Forest University)H-Index: 36
Last. Barbara J. Nicklas (Wake Forest University)H-Index: 62
view all 8 authors...
Importance More than 80% of patients with heart failure with preserved ejection fraction (HFPEF), the most common form of heart failure among older persons, are overweight or obese. Exercise intolerance is the primary symptom of chronic HFPEF and a major determinant of reduced quality of life (QOL). Objective To determine whether caloric restriction (diet) or aerobic exercise training (exercise) improves exercise capacity and QOL in obese older patients with HFPEF. Design, Setting, and Participa...
185 CitationsSource
#1Barbara J. Nicklas (Wake Forest University)H-Index: 62
#2Elizabeth Chmelo (Wake Forest University)H-Index: 9
Last. Anthony P. Marsh (Wake Forest University)H-Index: 21
view all 6 authors...
Background: Resistance training (RT) improves muscle strength and overall physical function in older adults. RT may be particularly important in the obese elderly who have compromised muscle function. Whether caloric restriction (CR) acts synergistically with RT to enhance function is unknown. Objective: As the primary goal of the Improving Muscle for Functional Independence Trial (I’M FIT), we determined the effects of adding CR for weight loss on muscle and physical function responses to RT in...
52 CitationsSource
Cited By2
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#1Salvatore Carbone (VCU: Virginia Commonwealth University)H-Index: 17
#2Carl J. Lavie (UQ: University of Queensland)H-Index: 84
Last. Hector O. Ventura (UQ: University of Queensland)H-Index: 57
view all 5 authors...
Obesity has reached worldwide epidemic proportions, adversely impacting health on a global scale. Overweight and obesity adversely impact cardiac structure and function, affecting systolic and diastolic ventricular function. Studies and meta-analyses have documented an obesity paradox in large heart failure cohorts, where overweight and obese individuals with established heart failure have a better short- and medium-term prognosis compared with lean patients; this relationship is strongly impact...
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Last. Giulio MarchesiniH-Index: 68
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Sarcopenic obesity (SO) is referred to as the combination of obesity with low skeletal muscle mass and function. However, its definition and diagnosis is debated. SO represents a sizable risk factor for the development of disability, possibly with a worse prognosis in women. The present narrative review summarizes the current evidence on pharmacological, nutrition and exercise strategies on the prevention and/or treatment of SO in middle-aged and older-aged women. A literature search was carried...
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#1John A. Batsis (The Dartmouth Institute for Health Policy and Clinical Practice)H-Index: 27
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