Abstract 374: Lack of Fibronectin Containing Extra Domain a Attenuates Acute Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Mice by Limiting Postischemic Thrombo-inflammation

Background: Reperfusion therapy is standard care for patients following acute myocardial infarction. Fibronectin-splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for toll-like-receptor 4 (TLR4), is upregulated during vascular hypertension, myocardial injury, and atherosclerosis. An earlier study done in rabbit showed that Fn-EDA accumulates more rapidly (within 24 hrs) in the reperfused hearts. Very little is...