Dural lymphatics regulate clearance of extracellular tau from the CNS
Abstract
Alzheimer’s disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble, hyperphosphorylated aggregates in the cell body. Aside from its role in AD, tau is also involved in several other neurodegenerative disorders collectively called tauopathies, such...
Paper Details
Title
Dural lymphatics regulate clearance of extracellular tau from the CNS
Published Date
Feb 27, 2019
Journal
Volume
14
Issue
1
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