Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system

Volume: 40, Issue: 5, Pages: 631 - 648
Published: Mar 9, 2019
Abstract
Genetic testing for cancer predisposition leads to the identification of a number of variants with uncertain significance. To some extent, variants of BRCA1/2 have been classified, in contrast to variants of other genes. CHEK2 is a typical example, in which a large number of variants of unknown clinical significance were identified and still remained unclassified. Herein, the CHEK2 variant assessment was performed through an in vivo,...
Paper Details
Title
Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system
Published Date
Mar 9, 2019
Volume
40
Issue
5
Pages
631 - 648
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