Divergent roles of prostacyclin and PGE2 in human tendinopathy

Tendon disease is a significant global healthcare burden whereby patients experience pain and disability; however, the mechanisms that underlie inflammation and pain are poorly understood. Herein, we investigated the role of prostaglandins as important mediators of inflammation and pain in tissues and cells derived from patients with tendinopathy. We studied supraspinatus and Achilles tendon biopsies from symptomatic patients with tendinopathy...