Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome
Abstract
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for which no cure exists. The disease is characterized by premature aging and inevitable death in adolescence due to cardiovascular complications. Most HGPS patients carry a heterozygous de novo LMNA c.1824C > T mutation, which provokes the expression of a dominant-negative mutant protein called progerin. Therapies proven effective in HGPS-like mouse models have...
Paper Details
Title
Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome
Published Date
Mar 19, 2019
Journal
Volume
5
Issue
1
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