Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics
Abstract
•Normal HSCs are stiffer and less deformable than mature blood cells•Ptpn21 loss decreases cell stiffness and increases mobility/deformability in HSCs•Deletion of Ptpn21 results in HSC egress due to impaired retention in the niche•Ptpn21 modulates cellular mechanics by dephosphorylation of Septin1 (Tyr246) Hematopoietic stem cell (HSC) quiescence is a tightly regulated process crucial for hematopoietic regeneration, which requires a healthy and...
Paper Details
Title
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics
Published Date
Apr 1, 2019
Journal
Volume
24
Issue
4
Pages
608 - 620.e6
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Notes
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