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Precision exercise medicine: understanding exercise response variability

Published on Sep 1, 2019in British Journal of Sports Medicine11.645
· DOI :10.1136/bjsports-2018-100328
Robert Ross51
Estimated H-index: 51
(UM: University of Michigan),
Bret H. Goodpaster81
Estimated H-index: 81
(Translational Research Institute)
+ 13 AuthorsClaude Bouchard136
Estimated H-index: 136
(Pennington Biomedical Research Center)
Sources
Abstract
There is evidence from human twin and family studies as well as mouse and rat selection experiments that there are considerable interindividual differences in the response of cardiorespiratory fitness (CRF) and other cardiometabolic traits to a given exercise programme dose. We developed this consensus statement on exercise response variability following a symposium dedicated to this topic. There is strong evidence from both animal and human studies that exercise training doses lead to variable responses. A genetic component contributes to exercise training response variability. In this consensus statement, we (1) briefly review the literature on exercise response variability and the various sources of variations in CRF response to an exercise programme, (2) introduce the key research designs and corresponding statistical models with an emphasis on randomised controlled designs with or without multiple pretests and post-tests, crossover designs and repeated measures designs, (3) discuss advantages and disadvantages of multiple methods of categorising exercise response levels—a topic that is of particular interest for personalised exercise medicine and (4) outline approaches that may identify determinants and modifiers of CRF exercise response. We also summarise gaps in knowledge and recommend future research to better understand exercise response variability.
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#2Carsten Lundby (UCPH: University of Copenhagen)H-Index: 13
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#1Anne Hecksteden (Saarland University)H-Index: 12
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Observed response to regular exercise training differs widely between individuals even in tightly controlled research settings. However, the respective contributions of random error and true interindividual differences as well as the relative frequency of non-responders are disputed. Specific challenges of analyses on the individual level as well as a striking heterogeneity in definitions may partly explain these inconsistent results. Repeated testing during the training phase specifically addre...
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