Cyclooxygenase selectivity and chemical subgroup of non-steroidal anti-inflammatory drugs and frequency of spontaneous reporting of hypersensitivity reactions: A case/non-case study in Vigibase

Background: Useofnon-steroidal anti-inflammatory drugs(NSAIDs) has been associated with many adverse events, including hypersensitivity reactions (HSRs), such as angioedemaand urticaria. However, no studies have investigated whether cyclooxygenase (COX) enzyme selectivity and/or chemical subgroups are associated with a difference in HSRs. Objectives: To describe and compare the frequency of HSRs among NSAIDs based on cyclooxygenase selectivity...