Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.

Volume: 10, Issue: 1, Pages: 1194
Published: Mar 18, 2019
Abstract
Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr serovars D, K and E for long-term in vitro analysis. The epithelial monolayer responds with active expulsion of the bacteria into the lumen and with compensatory cellular proliferation-demonstrating a role of epithelial homeostasis in the defense against this pathogen....
Paper Details
Title
Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.
Published Date
Mar 18, 2019
Volume
10
Issue
1
Pages
1194
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