Solidified phospholipid-TPGS as an effective oral delivery system for improving the bioavailability of resveratrol

Resveratrol (RES), a compound with a variety of pharmacological activities, is reported to be poorly soluble in water and has limited absorption in vivo. And so its application is limited. In this study, a solidified RES phospholipid (PL) complex solid dispersion, containing RES-PL complex (RPC) and Sylysia 350 (S350) together with D-a-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) (RPC-SDT) was prepared by simple...