scinapse is loading now...
  • References (49)
  • Citations (0)
Nadine Akbar7
Estimated H-index: 7
(University of Toronto),
Brenda Banwell55
Estimated H-index: 55
(University of Pennsylvania)
+ 5 AuthorsChristine Till16
Estimated H-index: 16
(York University)
ABSTRACTObjective: This study aimed to determine the extent and pattern of brain activation elicited by a functional magnetic resonance imaging version of the Symbol Digit Modalities Test (fMRI–SDMT), a task of information processing speed, in pediatric-onset multiple sclerosis (MS) patients as compared to sex- and age-matched non-MS self-reported healthy individuals. Method: Participants included 20 right-handed individuals aged 13–24 years with pediatric-onset MS (mean age = 19 years, 15 femal...
11 Citations Source Cite
Published on Jun 1, 2015in Multiple Sclerosis Journal 5.28
Maria A. Rocca71
Estimated H-index: 71
(Vita-Salute San Raffaele University),
Ermelinda De Meo2
Estimated H-index: 2
(Vita-Salute San Raffaele University)
+ 11 AuthorsLorena Pippolo4
Estimated H-index: 4
We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white ma...
15 Citations Source Cite
Published on Dec 1, 2014in Neuropsychology Review 4.89
Maureen Dennis41
Estimated H-index: 41
(University of Toronto),
Brenda J. Spiegler21
Estimated H-index: 21
(University of Toronto)
+ 6 AuthorsJack M. Fletcher58
Estimated H-index: 58
(University of Houston)
At every point in the lifespan, the brain balances malleable processes representing neural plasticity that promote change with homeostatic processes that promote stability. Whether a child develops typically or with brain injury, his or her neural and behavioral outcome is constructed through transactions between plastic and homeostatic processes and the environment. In clinical research with children in whom the developing brain has been malformed or injured, behavioral outcomes provide an inde...
15 Citations Source Cite
Published on Oct 14, 2014in Neurology 8.05
Maria Pia Amato54
Estimated H-index: 54
(University of Florence),
Benedetta Goretti29
Estimated H-index: 29
(University of Florence)
+ 15 AuthorsFrancesco Patti42
Estimated H-index: 42
(University of Catania)
Objective: The aim of the study was to perform a third cognitive assessment in our pediatric-onset multiple sclerosis (MS) patient cohort and determine predictors of the individual cognitive outcome. Methods: After 4.7 ± 0.7 years from baseline evaluation, 48 of 63 patients in the original cohort were reassessed on an extensive neuropsychological battery and compared with 46 healthy controls. Two alternate versions of the tests were used at different assessment points. Cognitive impairment was d...
46 Citations Source Cite
Published on May 1, 2014in NeuroImage 5.43
Choong-Wan Woo12
Estimated H-index: 12
(University of Colorado Boulder),
Anjali Krishnan8
Estimated H-index: 8
(University of Colorado Boulder),
Tor D. Wager67
Estimated H-index: 67
(University of Colorado Boulder)
article i nfo Article history: Accepted 30 December 2013 Available online xxxx Cluster-extent based thresholding is currently the most popular method for multiple comparisons correction of statistical maps in neuroimaging studies, due to its high sensitivity to weak and diffuse signals. However, cluster- extent based thresholding provides low spatial specificity; researchers can only infer that there is signal somewhere within a significant cluster and cannot make inferences about the statistica...
479 Citations Source Cite
Published on Feb 26, 2014in PLOS ONE 2.77
Rezwan Ghassemi8
Estimated H-index: 8
(Montreal Neurological Institute and Hospital),
Sridar Narayanan41
Estimated H-index: 41
(Montreal Neurological Institute and Hospital)
+ 3 AuthorsDouglas L. Arnold60
Estimated H-index: 60
(Montreal Neurological Institute and Hospital)
Introduction Onset of MS occurs during childhood in about 5% of cases. It is unclear whether very young age at MS onset, when the nervous system is still myelinating, affects MS lesion accrual or regional distribution.
39 Citations Source Cite
Published on Jan 1, 2014in Neuropsychologia 2.89
Isabelle Deschamps5
Estimated H-index: 5
(McGill University),
Shari R. Baum30
Estimated H-index: 30
(McGill University),
Vincent L. Gracco33
Estimated H-index: 33
(McGill University)
Abstract The supramarginal gyrus (SMG) is activated for phonological processing during both language and verbal working memory tasks. Using rTMS, we investigated whether the contribution of the SMG to phonological processing is domain specific (specific to phonology) or more domain general (specific to verbal working memory). A measure of phonological complexity was developed based on sonority differences and subjects were tested after low frequency rTMS on a same/different judgment task and an ...
45 Citations Source Cite
Published on Nov 1, 2012in Journal of Child Neurology 1.67
Sandra Bigi8
Estimated H-index: 8
(University of Toronto),
Brenda Banwell55
Estimated H-index: 55
(University of Toronto)
Pediatric multiple sclerosis has been increasingly recognized in the past 10 to 15 years; 3% to 5% of all multiple sclerosis patients experience their first attack in childhood. Childhood multiple sclerosis has a relapsing-remitting disease course. The first attack, or “acquired demyelinating syndrome,” consists of optic neuritis, transverse myelitis, acute disseminated encephalomyelitis, and monofocal or polyfocal neurological deficits. The diagnosis of multiple sclerosis necessitates the clini...
33 Citations Source Cite
Published on Aug 1, 2012in Archives of Clinical Neuropsychology 1.59
Christine Till16
Estimated H-index: 16
(York University),
C. Ho1
Estimated H-index: 1
(York University)
+ 3 AuthorsBrenda Banwell55
Estimated H-index: 55
(University of Toronto)
19 Citations Source Cite
Published on Apr 1, 2012in Neurobiology of Aging 4.45
Nicholas M. Kanaan24
Estimated H-index: 24
(Michigan State University),
Gerardo Morfini27
Estimated H-index: 27
(University of Illinois at Chicago)
+ 6 AuthorsScott T. Brady61
Estimated H-index: 61
(University of Illinois at Chicago)
Abstract Alzheimer's disease (AD) and other tauopathies are characterized by fibrillar inclusions composed of the microtubule-associated protein, tau. Recently, we demonstrated that the N-terminus of tau (amino acids [aa] 2–18) in filamentous aggregates or N-terminal tau isoforms activate a signaling cascade involving protein phosphatase 1 and glycogen synthase kinase 3 that results in inhibition of anterograde fast axonal transport (FAT). We have termed the functional motif comprised of aa 2–18...
61 Citations Source Cite
Cited By0