Identification of Syndecan-1 As a Key Dependency of Myeloid Leukemia Growth and Dissemination
Abstract
Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus identifying the cells responsible for residual disease and leukemia re-growth is critical to better understand how they are regulated. Here we show that a knock-in reporter mouse for the stem cell gene Musashi 2 (Msi2) allows identification of therapy resistant leukemia propagating cells in aggressive myeloid...
Paper Details
Title
Identification of Syndecan-1 As a Key Dependency of Myeloid Leukemia Growth and Dissemination
Published Date
Nov 29, 2018
Journal
Volume
132
Issue
Supplement 1
Pages
3003 - 3003
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