Match!

Fruit Consumption is Associated with Alterations in Microbial Composition and Lower Rates of Pouchitis

Published on Sep 27, 2019in Journal of Crohns & Colitis
· DOI :10.1093/ecco-jcc/jjz053
Lihi Godny1
Estimated H-index: 1
(Rabin Medical Center),
Nitsan Maharshak25
Estimated H-index: 25
(Tel Aviv Sourasky Medical Center)
+ 6 AuthorsIris Dotan2
Estimated H-index: 2
(Rabin Medical Center)
Abstract
BACKGROUND: Patients with ulcerative colitis [UC] who undergo proctocolectomy with an ileal pouch-anal anastomosis commonly develop pouch inflammation [pouchitis]. Pouchitis develops in a previously normal small intestine and may involve environmental factors. We explored whether diet and microbiota alterations contributed to the pathogenesis of pouchitis. METHODS: Patients were recruited and prospectively followed at a comprehensive pouch clinic. Pouch behaviour was clinically defined as a normal pouch [NP] or pouchitis. Patients completed Food Frequency Questionnaires [FFQs]. Faecal samples were analysed for microbial composition [16S rRNA gene pyrosequencing]. RESULTS: Nutritional evaluation was performed in 172 patients [59% females], and of these, faecal microbial analysis was performed in 75 patients (microbiota cohort: NP [n = 22], pouchitis [n = 53]). Of the entire cohort, a subgroup of 39 [22.6%] patients had NP at recruitment [NP cohort]. Of these, 5 [12.8%] developed pouchitis within a year. Patients at the lowest tertile of fruit consumption [<1.45 servings/day] had higher rates of pouchitis compared with those with higher consumption [30.8% vs 3.8%, log rank, p = 0.03]. Fruit consumption was correlated with microbial diversity [r = 0.35, p = 0.002] and with the abundance of several microbial genera, including Faecalibacterium [r = 0.29, p = 0.01], Lachnospira [r = 0.38, p = 0.001], and a previously uncharacterized genus from the Ruminococcaceae family [r = 0.25, p = 0.05]. Reduction in fruit consumption over time was associated with disease recurrence and with reduced microbial diversity [Δ = -0.8 ± 0.3, p = 0.008]. CONCLUSIONS: Fruit consumption is associated with modification of microbial composition, and lower consumption was correlated with the development of pouchitis. Thus, fruit consumption may protect against intestinal inflammation via alteration of microbial composition.
  • References (48)
  • Citations (3)
📖 Papers frequently viewed together
4 Citations
20152.78PLOS ONE
115 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References48
Newest
#1Henit Yanai (TAU: Tel Aviv University)H-Index: 15
#2Shay Ben-Shachar (TAU: Tel Aviv University)H-Index: 14
Last. Iris Dotan (TAU: Tel Aviv University)H-Index: 35
view all 7 authors...
1 CitationsSource
#1Sean R. Llewellyn (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 4
#2Graham J. Britton (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 4
Last. Jeremiah J. Faith (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 27
view all 10 authors...
Abstract Background & Aims It is not clear how the complex interactions between diet and the intestinal microbiota affect development of mucosal inflammation or inflammatory bowel disease. We investigated interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice given more than 40 unique diets; we quantified individual and synergistic effects of dietary macronutrients and the microbiota on intestinal health and development of ...
52 CitationsSource
#1Wing Sun Faith Chung (Aberd.: University of Aberdeen)H-Index: 3
#2Marjolein MeijerinkH-Index: 17
Last. Sylvia H. Duncan (Aberd.: University of Aberdeen)H-Index: 58
view all 9 authors...
Dietary plant cell wall carbohydrates are important in modulating the composition and metabolism of the complex gut microbiota, which can impact on health. Pectin is a major component of plant cell walls. Based on studies in model systems and available bacterial isolates and genomes, the capacity to utilise pectins for growth is widespread among colonic Bacteroidetes but relatively uncommon among Firmicutes. One Firmicutes species promoted by pectin is Eubacterium eligens. Eubacterium eligens DS...
62 CitationsSource
#1Dror S. Shouval (TAU: Tel Aviv University)H-Index: 10
#2Paul A. Rufo (Harvard University)H-Index: 14
Importance Inflammatory bowel diseases (IBD), such as Crohn disease and ulcerative colitis, are chronic relapsing conditions that affect a growing number of children worldwide. The pathogenesis of these disorders is complex and thought to be mediated by the interplay between genetic susceptibility, microbial dysbiosis, and environmental factors that result in a dysregulated immune system. This dysregulation ultimately mediates intestinal inflammation and clinical symptoms typically observed in p...
21 CitationsSource
#1Gilaad G. Kaplan (U of C: University of Calgary)H-Index: 49
#2Siew C. Ng (CUHK: The Chinese University of Hong Kong)H-Index: 50
The inflammatory bowel diseases (IBDs) are contemporary conditions of industrialized societies. The prevalence of IBD continues to increase steadily in Western countries, and newly industrialized countries have a rapidly increasing incidence. The global spread of IBD appears to associate with Westernization of diets and environments, which affects the intestinal microbiome and increases the risk of IBD in genetically susceptible individuals. It is important to increase our understanding of these...
151 CitationsSource
#1James D. Lewis (UPenn: University of Pennsylvania)H-Index: 76
#2Maria T. Abreu (UM: University of Miami)H-Index: 50
The most common question asked by patients with inflammatory bowel disease (IBD) is, "Doctor, what should I eat?" Findings from epidemiology studies have indicated that diets high in animal fat and low in fruits and vegetables are the most common pattern associated with an increased risk of IBD. Low levels of vitamin D also appear to be a risk factor for IBD. In murine models, diets high in fat, especially saturated animal fats, also increase inflammation, whereas supplementation with omega 3 lo...
75 CitationsSource
#1Mahesh S. Desai (UM: University of Michigan)H-Index: 11
#2Anna M. Seekatz (UM: University of Michigan)H-Index: 11
Last. Eric C. Martens (UM: University of Michigan)H-Index: 34
view all 16 authors...
Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic mouse model, in which animals were colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut microbiota, and the colonic mucus barrier, which serves as a primary defense against enteric pa...
411 CitationsSource
#1Nitsan Maharshak (Tel Aviv Sourasky Medical Center)H-Index: 25
#2Nathaniel Aviv Cohen (Tel Aviv Sourasky Medical Center)H-Index: 3
Last. Iris Dotan (Tel Aviv Sourasky Medical Center)H-Index: 35
view all 6 authors...
Objective: To examine whether patients with a mature normal pouch [> 1 year post ileostomy closure] have microbial stool characteristics that can predict pouch inflammation. Design: Patients undergoing pouch surgery were recruited prospectively. Microbiota analysis of faecal samples was by 16S rRNA gene pyrosequencing. All patients had a normal pouch at baseline [T1]. Those without pouchitis during the first year of follow-up [T2] comprised the ‘Normal Pouch-sustained’ group and those who had ex...
8 CitationsSource
#1O. Niewiadomski (University of Melbourne)H-Index: 1
#2Corrie Studd (Royal Hobart Hospital)H-Index: 7
Last. Sally Bell (University of Melbourne)H-Index: 28
view all 14 authors...
Background The Barwon area in Australia has one of the highest incidence rates of inflammatory bowel disease (IBD) and therefore is an ideal location to study the impact of environmental exposures on the disease's development. Aim To study these exposures prior to the development of IBD in a population-based cohort. Method One hundred and thirty-two incident cases (81 Crohn disease (CD) and 51 ulcerative colitis (UC)) from an IBD registry and 104 controls replied to the International Organizatio...
24 CitationsSource
#1Gwen Falony (Katholieke Universiteit Leuven)H-Index: 25
#2Marie Joossens (Vrije Universiteit Brussel)H-Index: 24
Last. Jeroen Raes (Vrije Universiteit Brussel)H-Index: 70
view all 27 authors...
Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnai...
481 CitationsSource
Cited By3
Newest
#1Sabrina Just Kousgaard (AAU: Aalborg University)H-Index: 2
#2Hans Linde Nielsen (AAU: Aalborg University)H-Index: 12
Last. Ole Thorlacius-Ussing (AAU: Aalborg University)H-Index: 19
view all 4 authors...
PURPOSE The gut microbiota is conceivably a key factor in the aetiology of pouchitis. Faecal microbiota transplantation (FMT) has been suggested as a promising new treatment for chronic pouchitis, where treatment options often are few. However, little is known about the influence of the diet on the clinical effects of FMT. We assessed the diet of patients with chronic pouchitis undergoing FMT to investigate the influence of diet on the clinical outcome after FMT. METHODS Nine patients with chron...
Source
#1Kevin Whelan ('KCL': King's College London)H-Index: 42
Source
#1Philipp SchreinerH-Index: 2
Last. Luc BiedermannH-Index: 19
view all 6 authors...
BACKGROUND: Westernization, above all associated changes in diet, has been postulated to be one of the most important factors contributing to the increasing incidence in inflammatory bowel disease (IBD), consisting mainly of Crohn's disease and ulcerative colitis. SUMMARY: Diet represents a crucially important and intuitively relevant topic for IBD patients. Although a substantial number of patients are prone to follow dietary advice from a variety of sources, including the lay press, there is i...
2 CitationsSource
#1Lihi Godny (Rabin Medical Center)H-Index: 1
#2Leah Reshef (TAU: Tel Aviv University)H-Index: 9
Last. Iris Dotan (Rabin Medical Center)H-Index: 2
view all 8 authors...
Background Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery.
Source
#1Allison Bigeh (UA: University of Arizona)
#2Alexandra M. Sanchez (Holy Cross Hospital)H-Index: 1
Last. Martha Gulati (UA: University of Arizona)H-Index: 26
view all 4 authors...
Abstract Inflammation has a strong role in the development of atherosclerotic cardiovascular disease (ASCVD). Several systemic inflammatory conditions have been linked to an increased risk of ASCVD; however, this has not been well established in Inflammatory Bowel Disease (IBD). IBD is comprised of Ulcerative Colitis and Crohn's disease, both of which involve chronic inflammation of the intestinal tract, often with evidence of systemic involvement. Several ASCVD risk factors such as smoking, dia...
1 CitationsSource
#2Beatriz MateosH-Index: 1
Last. Belén BeltránH-Index: 25
view all 7 authors...
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory condition of the gastrointestinal tract; it is a heterogeneous and multifactorial disorder resulting from a complex interplay between genetic variation, intestinal microbiota, the host immune system and environmental factors such as diet, drugs, breastfeeding and smoking. The interactions between dietary nutrients and intestinal immunity are complex. There is a compelling argument for environmental factors such as diet play...
2 CitationsSource