When bigger isn't better: understanding the anabolic resistance of obese skeletal muscle

In addition to being responsible for generating mechanical work, skeletal muscle is an important tissue for glucose disposal and overall metabolic health and, thus, should be maintained at an optimal quantity and quality across the lifespan. This is facilitated through constant remodelling of skeletal muscle via muscle protein synthesis (MPS) and muscle protein breakdown (MPB). In healthy adults, MPS and MPB are approximately equal over the...