Match!

Heat stress, Eimeria spp. and C. perfringens infections alone or in combination modify gut Th1/Th2 cytokine balance and avian necrotic enteritis pathogenesis

Published on Apr 1, 2019in Veterinary Immunology and Immunopathology1.85
· DOI :10.1016/j.vetimm.2019.03.001
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
W.M. Quinteiro-Filho12
Estimated H-index: 12
(USP: University of São Paulo)
+ 9 AuthorsJoão Palermo-Neto30
Estimated H-index: 30
(USP: University of São Paulo)
Abstract
Abstract Information on the dynamics of the chicken immune system during bacterial or parasite challenge in the presence or absence of stressful situations may provide a better understanding of the complex mechanisms behind these diseases. Necrotic enteritis (NE) had been controlled previously by the proper use of antimicrobial agents; however, more recently, NE has reemerged in many countries. The imposed restrictions on antimicrobial use and/or the intensive productive programs implemented by producers are challenges the birds, leading to large host adaptive responses that in many instances are like those elicited by stressors. This study analyses the effects of heat stress on Th1/Th2 cytokine balance, pathological features, and Toll-like receptor expression in the small intestine of broiler chickens infected with Clostridium perfringens type A in the presence or absence of Eimeria spp. co-infection. This co-infection model was experimentally used because it reproduces the findings commonly observed in the field during avian NE. For this purpose, broiler chickens infected with C. perfringens and/or Eimeria spp. were reared in isolator chambers subjected or not to heat stress intermittently. It was observed that heat stress directs the expression of Th2-type cytokines, increases Toll-like receptor 4 expression in the intestine and reduces the disease severity induced by Eimeria spp. and C. perfringens infections alone or in combination, most likely as a consequence of stress-induced changes in brain-gut axis activity.
  • References (37)
  • Citations (0)
References37
Newest
9 CitationsSource
#1Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 7
#2Adriana de Siqueira (USP: University of São Paulo)H-Index: 7
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 9 authors...
9 CitationsSource
#1V. TsiourisH-Index: 3
#2I. GeorgopoulouH-Index: 7
Last.P. D. Fortomaris (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 14
view all 6 authors...
10 CitationsSource
#1Bruno Takashi Bueno Honda (USP: University of São Paulo)H-Index: 3
#2Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 7
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 7 authors...
13 CitationsSource
#1Tsiouris (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 2
#2I. Georgopoulou (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 7
Last.P. D. Fortomaris (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 14
view all 6 authors...
18 CitationsSource
#1Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 7
#2Bruno Takashi Bueno Honda (USP: University of São Paulo)H-Index: 3
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 10 authors...
14 CitationsSource
#1A.V. Gomes (USP: University of São Paulo)H-Index: 3
#2W.M. Quinteiro-Filho (USP: University of São Paulo)H-Index: 12
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 10 authors...
35 CitationsSource
#1Vanja Lazarevic (National Cancer Research Institute)H-Index: 18
#2Laurie H. Glimcher (Cornell University)H-Index: 121
Last.Graham M. LordH-Index: 46
view all 3 authors...
209 CitationsSource
#1W.M. Quinteiro-Filho (USP: University of São Paulo)H-Index: 12
#2A.V. Gomes (USP: University of São Paulo)H-Index: 3
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 8 authors...
72 CitationsSource
#1Kyung-Woo Lee (ARS: Agricultural Research Service)H-Index: 24
#2Hyun S. Lillehoj (ARS: Agricultural Research Service)H-Index: 49
Last.Dong-Jun An (South Korean Ministry for Food, Agriculture, Forestry and Fisheries)H-Index: 18
view all 5 authors...
73 CitationsSource
Cited By0
Newest
View next paperImmunopathology and Cytokine Responses in Broiler Chickens Coinfected with Eimeria maxima and Clostridium perfringens with the Use of an Animal Model of Necrotic Enteritis