Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

Heat stress, Eimeria spp. and C. perfringens infections alone or in combination modify gut Th1/Th2 cytokine balance and avian necrotic enteritis pathogenesis

Published on Apr 1, 2019in Veterinary Immunology and Immunopathology 1.63
· DOI :10.1016/j.vetimm.2019.03.001
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo)
+ 9 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Abstract
Abstract Information on the dynamics of the chicken immune system during bacterial or parasite challenge in the presence or absence of stressful situations may provide a better understanding of the complex mechanisms behind these diseases. Necrotic enteritis (NE) had been controlled previously by the proper use of antimicrobial agents; however, more recently, NE has reemerged in many countries. The imposed restrictions on antimicrobial use and/or the intensive productive programs implemented by producers are challenges the birds, leading to large host adaptive responses that in many instances are like those elicited by stressors. This study analyses the effects of heat stress on Th1/Th2 cytokine balance, pathological features, and Toll-like receptor expression in the small intestine of broiler chickens infected with Clostridium perfringens type A in the presence or absence of Eimeria spp. co-infection. This co-infection model was experimentally used because it reproduces the findings commonly observed in the field during avian NE. For this purpose, broiler chickens infected with C. perfringens and/or Eimeria spp. were reared in isolator chambers subjected or not to heat stress intermittently. It was observed that heat stress directs the expression of Th2-type cytokines, increases Toll-like receptor 4 expression in the intestine and reduces the disease severity induced by Eimeria spp. and C. perfringens infections alone or in combination, most likely as a consequence of stress-induced changes in brain-gut axis activity.
  • References (37)
  • Citations (0)
Cite
References37
Newest
Published on May 1, 2016in Poultry Science 2.22
Atilio Sersun Calefi7
Estimated H-index: 7
,
Juliana Garcia da Silva Fonseca4
Estimated H-index: 4
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
The gut-brain axis is known to modulate behavioral and immune responses in animals; evidence supporting this modulation in chickens, however, is elusive. Here, we analyzed the effects of heat stress and/orClostridium perfringens (CP) infection on behavior, intestinal morphology, brain activity, and corticosterone serum levels in chickens. Broilers were randomly divided into 5 equal groups: a naive group (N), a thioglycolate group (T), a thioglycolate heat-stressed group (T/HS35), an infected gro...
8 Citations Source Cite
Published on Mar 1, 2016in Veterinary Immunology and Immunopathology 1.63
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Adriana de Siqueira6
Estimated H-index: 6
(USP: University of São Paulo)
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Abstract Avian necrotic enteritis (NE) induced by Clostridium perfringens is a disease that affects mainly the first weeks of poultry’s life. The pathogenesis of NE is complex and involves the combination of several factors, such as co-infection with different species of coccidia, immunosuppression and stress. Stress is one of the main limiting factors in poultry production. Although several studies emphasized the effects of stress on immunity, few works analyzed these effects on immunoglobulins...
8 Citations Source Cite
Published on Nov 2, 2015in Avian Pathology 2.05
V. Tsiouris2
Estimated H-index: 2
,
I. Georgopoulou7
Estimated H-index: 7
+ 3 AuthorsP. Fortomaris5
Estimated H-index: 5
(A.U.Th.: Aristotle University of Thessaloniki)
Cold stress is a physical environmental stressor with significant effect on the poultry industry. The aim of the present study was to investigate the effect of cold stress as a predisposing factor for necrotic enteritis in broiler chicks. The experimental challenge model included an oral inoculation with 10-fold dose of attenuated anticoccidial vaccine and multiple oral inoculations with a specific strain of Clostridium perfringens. Birds were either challenged or not as described above, and eit...
9 Citations Source Cite
Published on Oct 1, 2015in Poultry Science 2.22
Bruno Takashi Bueno Honda3
Estimated H-index: 3
(USP: University of São Paulo),
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo)
+ 4 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Multiple factors, such as environment, nutritional status, and disease, induce stress in animals during livestock production. It has been shown that poultry exposed to stressors for prolonged periods had decreases in their performance parameters, mortality and decreased host resistance to pathogenic agents. It seems that early age stress may have long-lasting impact and could possibly modify the expression of their genetic potential on growth performance and immunity. This study aimed to discuss...
10 Citations Source Cite
Published on Mar 4, 2015in Avian Pathology 2.05
Tsiouris2
Estimated H-index: 2
(A.U.Th.: Aristotle University of Thessaloniki),
I. Georgopoulou7
Estimated H-index: 7
(A.U.Th.: Aristotle University of Thessaloniki)
+ 3 AuthorsP. Fortomaris5
Estimated H-index: 5
(A.U.Th.: Aristotle University of Thessaloniki)
Stocking density is a management factor which has critical implications for the poultry industry. The aim of the present study was to investigate the effect of high stocking density as a predisposing factor in an experimental model of necrotic enteritis in broiler chicks. The experimental challenge model included an oral inoculation with 10-fold dose of attenuated anticoccidial vaccine and multiple oral inoculations with a specific strain of Clostridium perfringens. Two hundred and forty as hatc...
16 Citations Source Cite
Published on Jun 1, 2014in Poultry Science 2.22
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Bruno Takashi Bueno Honda3
Estimated H-index: 3
(USP: University of São Paulo)
+ 7 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
14 Citations Source Cite
Published on Jan 2, 2014in Avian Pathology 2.05
A.V. Gomes3
Estimated H-index: 3
(USP: University of São Paulo),
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo)
+ 7 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Overcrowding stress is a reality in the poultry industry. Chickens exposed to long-term stressful situations present a reduction of welfare and immunosuppression. We designed this experiment to analyse the effects from overcrowding stress of 16 birds/m2 on performance parameters, serum corticosterone levels, the relative weight of the bursa of Fabricius, plasma IgA and IgG levels, intestinal integrity, macrophage activity and experimental Salmonella Enteritidis invasion. The results of this stud...
31 Citations Source Cite
Published on Nov 1, 2013in Nature Reviews Immunology 41.98
Vanja Lazarevic17
Estimated H-index: 17
(National Cancer Research Institute),
Laurie H. Glimcher120
Estimated H-index: 120
(Cornell University),
Graham M. Lord45
Estimated H-index: 45
The transcription factor T-bet is best known to immunologists as a master regulator of T helper 1 cell differentiation. However, it is becoming apparent that T-bet has important functions in other leukocyte populations, including memory CD8+ T cells, B cells, innate lymphoid cells, dendritic cells and natural killer cells. This Review discusses these emerging immunological roles for T-bet.
191 Citations Source Cite
Published on Oct 1, 2012in Avian Pathology 2.05
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo),
A.V. Gomes3
Estimated H-index: 3
(USP: University of São Paulo)
+ 5 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Stressful situations reduce the welfare, production indices and immune status of chickens. Salmonella spp. are a major zoonotic pathogens that annually cause over 1 billion infections worldwide. We therefore designed the current experiment to analyse the effects of 31±1°C heat stress (HS) (from 35 to 41 days) on performance parameters, Salmonella invasion and small intestine integrity in broiler chickens infected with Salmonella Enteritidis. We observed that HS decreased body weight gain and fee...
63 Citations Source Cite
Published on Jul 1, 2011in Poultry Science 2.22
Kyung-Woo Lee23
Estimated H-index: 23
(ARS: Agricultural Research Service),
Hyun S. Lillehoj48
Estimated H-index: 48
(ARS: Agricultural Research Service)
+ 2 AuthorsDong-Jun An16
Estimated H-index: 16
(South Korean Ministry for Food, Agriculture)
The increasing trends of legislative restrictions and voluntary removal of antibiotic growth promoters worldwide has already affected, and will continue to affect, poultry production and animal health. Necrotic enteritis (NE) is being considered among the most important infectious diseases in the current poultry production system globally, with an estimated annual economic loss of more than $2 billion, largely attributable to medical treatments and impaired growth performance. Thus, there is an ...
67 Citations Source Cite
Cited By0
Newest