Inflammatory Proteins Predict Change in Depressive Symptoms in Male and Female Adolescents

Inflammation has been implicated in depressive symptoms, but few studies use longitudinal designs with adolescents. Furthermore, the extant literature has yielded inconsistent results. Blood was collected from a community sample of 201 adolescents (109 female, age range = 12.3–20.0 years) and analyzed for inflammatory proteins. Up to five follow-up assessments of depressive symptoms were conducted. Multilevel modeling indicated that high...