Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
Abstract
VEGFA signaling controls physiological and pathological angiogenesis and hematopoiesis. Although many context-dependent signaling pathways downstream of VEGFA have been uncovered, vegfa transcriptional regulation in vivo remains unclear. Here, we show that the ETS transcription factor, Etv6, positively regulates vegfa expression during Xenopus blood stem cell development through multiple transcriptional inputs. In agreement with its established...
Paper Details
Title
Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
Published Date
Mar 6, 2019
Journal
Volume
10
Issue
1
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