TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells
Abstract
Left ventricular hypertrophy is an independent risk factor in diabetic patients. TGR5 is shown to express in hearts, but its functional role in diabetes-induced cardiac hypertrophy remained unclear. The current study investigated the role of TGR5 on high glucose-induced hypertrophy of H9C2 cells. After incubation with a high level of glucose, H9C2 cells showed hypertrophic responses. Activation of TGR5 by lithocholic acid (LCA) ameliorated cell...
Paper Details
Title
TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells
Published Date
Mar 6, 2019
Journal
Volume
9
Issue
1
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