Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders
Abstract
Two enveloped viral vectors, vesicular stomatitis virus and influenza virus, and a non-enveloped viral vector, human adenovirus type 5, were encapsulated by spray drying to enhance thermal stability.Results with these candidates led to the hypothesis that stability performance of chosen excipients may be less virus-specific, as previously postulated in the literature, and more differentiated based on whether the virus has a lipid envelope. Spray...
Paper Details
Title
Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders
Published Date
Apr 1, 2019
Volume
561
Pages
66 - 73
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