Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
Abstract
Overexpression of the B7-H1 (PD-L1) molecule in the tumor microenvironment (TME) is a major immune evasion mechanism in some patients with cancer, and antibody blockade of the B7-H1/PD-1 interaction can normalize compromised immunity without excessive side-effects. Using a genome-scale T cell activity array, we identified Siglec-15 as a critical immune suppressor. While only expressed on some myeloid cells normally, Siglec-15 is broadly...
Paper Details
Title
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
Published Date
Mar 4, 2019
Journal
Volume
25
Issue
4
Pages
656 - 666
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