RECURRENT GENOMIC COPY NUMBER VARIANTS IMPLICATE NEW CANDIDATE GENES FOR EARLY ONSET BICUSPID AORTIC VALVE DISEASE

Bicuspid Aortic Valve (BAV), the most common adult congenital heart defect, is a major cause of aortic insufficiency or stenosis requiring valve replacement and thoracic aortic aneurysms predisposing to acute aortic dissections. The spectrum of BAV ranges from early onset valve and...