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Emergence of Antimicrobial Resistance, Causes, Molecular Mechanisms, and Prevention Strategies: A Bovine Perspective

Published on Feb 27, 2019
· DOI :10.5772/intechopen.79757
M. Y. Ashraf14
Estimated H-index: 14
,
Behar-E Mustafa + 2 AuthorsMuhammad Adnan Ashraf
Abstract
  • References (47)
  • Citations (0)
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References47
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#1Jaffar A. Al-Tawfiq (IU: Indiana University)H-Index: 36
#2Ramanan Laxminarayan (Princeton University)H-Index: 48
Last. Marc Mendelson (UCT: University of Cape Town)H-Index: 24
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Summary Objective The widespread use of antibiotics in humans and animals has contributed to growing rates of antibiotic resistance. Previously treatable bacterial infections now require the last line of antibiotics or are untreatable. The current antibiotic of last resort for carbapenem-resistant Gram-negative bacterial infections is often colistin. Evidence for the shifting pattern of colistin resistance and how the international community should respond are discussed in this review. Methods T...
41 CitationsSource
#1Mohamed Rhouma (UdeM: Université de Montréal)H-Index: 7
#2Francis Beaudry (UdeM: Université de Montréal)H-Index: 24
Last. Ann LetellierH-Index: 20
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Colistin, a cationic polypeptide antibiotic, has reappeared in human medicine as a last-line treatment option for multidrug-resistant Gram-negative bacteria (MDR-GNB). Colistin is widely used in veterinary medicine for the treatment of gastrointestinal infections caused by Enterobacteriaceae. GNB resistant to colistin owing to chromosomal mutations have already been reported both in human and veterinary medicine, however several recent studies have just identified a plasmid-mediated mcr-1 gene e...
37 CitationsSource
#1Basil Britto Xavier (University of Antwerp)H-Index: 11
#2Christine Lammens (University of Antwerp)H-Index: 28
Last. Surbhi Malhotra-Kumar (University of Antwerp)H-Index: 29
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29 CitationsSource
#1Yiyun Liu (SCAU: South China Agricultural University)H-Index: 5
#2Yang Wang (CAU: China Agricultural University)H-Index: 40
Last. Jianzhong Shen (CAU: China Agricultural University)H-Index: 43
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Summary Background Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a routine surveillance project on antimicrobial resistance in commensal Escherichia coli from food animals in China, a major increase of colistin resistance was observed. When an E coli strain, SHP45, possessing colistin resistance that could be transferred to another strain, was isolated from a pig, we conducted further analysis of possible plasm...
1,602 CitationsSource
#1Boudewijn CatryH-Index: 27
#2Marco Cavaleri (European Medicines Agency)H-Index: 11
Last. Jordi Torren Edo (European Medicines Agency)H-Index: 1
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Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. Sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacteriaceae (e.g., Escherichia coli, Klebsiella pneumoniae), for which mortality can be high. In veterinary medicine, colistin has been used for decades for the treat...
72 CitationsSource
#2Françoise Van Bambeke (UCL: Université catholique de Louvain)H-Index: 42
Last. Gunnar Kahlmeter (Uppsala University)H-Index: 43
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In the face of increasing antimicrobial resistance and the paucity of new antimicrobial agents it has become clear that new antimicrobial strategies are urgently needed. One of these is to revisit old antibiotics to ensure that they are used correctly and to their full potential, as well as to determine whether one or several of them can help alleviate the pressure on more recent agents. Strategies are urgently needed to 're-develop' these drugs using modern standards, integrating new knowledge ...
39 CitationsSource
#1Anjelique Schulfer (NYU: New York University)H-Index: 4
#2Martin J. Blaser (NYU: New York University)H-Index: 133
During birth, a relatively sterile unborn child becomes a newborn coated with microbes on every surface. This collection of bacteria, archaea, viruses, and fungi found in and on the human body is called the microbiota. The collective genomes of the microbiota are considered to be the metagenome, and the totality of the microbiota, metagenome, and their interactions is the microbiome. The microbiota has many critical functions including protection from pathogens, development and maintenance of th...
40 CitationsSource
#1Amy J. MathersH-Index: 8
#2Gisele Peirano (U of C: University of Calgary)H-Index: 23
Last. Johann D. D. PitoutH-Index: 55
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SUMMARY Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in the 2000s as important human pathogens, have spread extensively throughout the world, and are responsible for the rapid increase in antimicrobial resistance among E. coli and K. pneumoniae strains, respectively. E. coli ST131 causes extraintestinal infections and is often fluoroquinolone resistant and associated with extended-spectrum β-lactamase production, especially CTX-M-15. K. pneumoniae ST258 caus...
243 CitationsSource
#1Yael R. Nobel (NYU: New York University)H-Index: 3
#2Laura M. Cox (NYU: New York University)H-Index: 18
Last. Martin J. Blaser (NYU: New York University)H-Index: 133
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Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic perturbation or nutrient flux. In humans, especially children, microbiota disruption is common, yet the dynamic microbiome recovery from early-life antibiotics is still uncharacterized. Here we use a mouse model mimicking paediatric antibiotic use and find that therapeutic-dose pulsed antibiotic treatment (PAT) with a beta-lactam or macrolide...
155 CitationsSource
#1Anyun Zhang (Sichuan University)H-Index: 14
#2Chang-Wen Xu (Sichuan University)H-Index: 9
Last. Linyao Peng (Sichuan University)H-Index: 3
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Abstract Erysipelothrix rhusiopathiae is a Gram-positive bacillus that causes erysipelas in swine. In recent years, erysipelas infection among swine in China has been increasing. A combined resistance phenotype to pleuromutilins, lincosamides, and streptogramin A (PLS A phenotype) was found in some E. rhusiopathiae isolates. The aim of this study was to identify the resistance genes responsible for the PLS A phenotype in E. rhusiopathiae strains and to map the genetic environment of the identifi...
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