Upregulation of DLEU1 expression by epigenetic modification promotes tumorigenesis in human cancer

Volume: 234, Issue: 10, Pages: 17420 - 17432
Published: Feb 21, 2019
Abstract
The function of DLEU1 in human cancer is largely unknown. The Cancer Genome Atlas data were applied to identify the landscape of differential genes between tumor tissues and normal tissues, which was further validated by our cohort data and pan-cancer data including 33 cancer types with 11,060 patients. Next, DLEU1 was selected to validate the novel finding and result showed that it promoted tumorigenesis in vitro and in vivo. Mechanistically,...
Paper Details
Title
Upregulation of DLEU1 expression by epigenetic modification promotes tumorigenesis in human cancer
Published Date
Feb 21, 2019
Volume
234
Issue
10
Pages
17420 - 17432
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