Notch Signaling Mediates Secondary Senescence

Volume: 27, Issue: 4
Published: Apr 23, 2019
Abstract
Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary...
Paper Details
Title
Notch Signaling Mediates Secondary Senescence
Published Date
Apr 23, 2019
Volume
27
Issue
4
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.