Notch Signaling Mediates Secondary Senescence
Abstract
Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary...
Paper Details
Title
Notch Signaling Mediates Secondary Senescence
Published Date
Apr 23, 2019
Journal
Volume
27
Issue
4
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