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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

Published on Dec 1, 2019in Nature Communications11.88
· DOI :10.1038/s41467-019-08469-7
Michelle Daya10
Estimated H-index: 10
(University of Colorado Denver),
Nicholas Rafaels26
Estimated H-index: 26
(University of Colorado Denver)
+ 62 AuthorsKathleen C. Barnes59
Estimated H-index: 59
(University of Colorado Denver)
Abstract
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations. The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.
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