Amygdala-prefrontal cortex white matter tracts are widespread, variable and implicated in amygdala modulation in adolescents

The amygdala is critically involved in processing emotion. Through bidirectional connections, the prefrontal cortex (PFC) is hypothesized to influence amygdala reactivity. However, research that elucidates the nature of amygdala-PFC interactions – through mapping amygdala-prefrontal tracts, quantifying variability among tracts, and linking this variability to amygdala activation – is lacking. Using probabilistic tractography to map...