An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death
Abstract
Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. We report a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis. The toxin, MbcT, is bactericidal unless neutralized by its antitoxin MbcA. To investigate the mechanism, we solved the 1.8 Å-resolution crystal structure of the MbcTA complex. We found that MbcT resembles secreted...
Paper Details
Title
An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death
Published Date
Mar 1, 2019
Journal
Volume
73
Issue
6
Pages
1282 - 1291.e8
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