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Biopharmaceutical benchmarks—2003

Published on Aug 1, 2003in Nature Biotechnology
· DOI :10.1038/nbt0803-865
Gary Walsh23
Estimated H-index: 23
(UL: University of Limerick)
Abstract
  • References (8)
  • Citations (130)
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s we approach the end of 2002, biotechnology companies continue to be the standard bearers for innovation in the pharmaceutical industry. And, according to a new publication from Scrip Reports (www.pjbpubs.com), even faster progress is expected following the initial sequencing of the complete human genome and the move to the new frontiers of proteomics (1). The U.S. biotech market is still the industry leader, with revenues of $22.4 billion in 2000. Yet, by comparison, the European biotech marke...
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Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient. One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells. Based on the nature of the viral genome, these gene therapy vectors can be divided into RNA and DNA viral vectors. The majority of RNA virus-based vectors have been derived from simple retroviruses lik...
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Antisense oligonucleotides, ribozymes and DNAzymes have emerged as novel, highly selective inhibitors or modulators of gene expression. Indeed, their use in the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. The first antisense drug molecule is now available for clinical use in Europe and USA. However, their successful application in the clinic will require improvements in cellular targeting and intracellular delivery. This review ...
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The ability to safely and efficiently transfer foreign DNA into cells is a fundamental goal in biotechnology. Toward this end, rapid advances have recently been made in our understanding of mechanisms for DNA stability and transport within cells. Current synthetic DNA delivery systems are versatile and safe, but substantially less efficient than viruses. Indeed, most current systems address only one of the obstacles to DNA delivery by enhancing DNA uptake. In fact, the effectiveness of gene expr...
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