A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation
Abstract
Poor success rates and challenges associated with the current therapeutic strategies of inflammatory bowel disease (IBD) have accelerated the emergence of gene therapy as an alternative treatment option with great promise. However, oral delivery of nucleic acids (NAs) to an inflamed colon is challenged by multiple barriers presented by the gastrointestinal, extracellular and intracellular compartments. Therefore, we screened a series of...
Paper Details
Title
A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation
Published Date
Jan 1, 2019
Journal
Volume
11
Issue
11
Pages
4970 - 4986
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