A novel STIM1-Orai1 gating interface essential for CRAC channel activation
Abstract
Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca2+ release-activated Ca2+ (CRAC) channel. STIM1, a key molecular component of this process, is located in the membrane of the endoplasmic reticulum (ER) and is initially activated upon Ca2+ store depletion. This activation signal is transmitted to the plasma membrane...
Paper Details
Title
A novel STIM1-Orai1 gating interface essential for CRAC channel activation
Published Date
May 1, 2019
Journal
Volume
79
Pages
57 - 67
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