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Risikofaktoren für die Entstehung und den Verlauf der Schizophrenie

Published on Feb 1, 2019in Fortschritte Der Neurologie Psychiatrie0.635
· DOI :10.1055/a-0836-7839
Lisa Löhrs2
Estimated H-index: 2
,
Alkomiet Hasan31
Estimated H-index: 31
Abstract
Gemas dem derzeitigen Wissen entsteht eine Schizophrenie multifaktoriell – und zwar durch kumulative Wirkung einzelner, fur sich unterschwelliger Risikofaktoren. Diese Faktoren (u. a. genetische, psychosoziale, umweltbedingte, pra- und peripartale) ziehen strukturelle Gehirnveranderungen und Veranderungen einzelner Neurotransmittersysteme nach sich, die schlieslich zum Vollbild der Schizophrenie fuhren.
  • References (29)
  • Citations (2)
References29
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#1Robin M. Murrayand ('KCL': King's College London)H-Index: 149
#2Amir Englund ('KCL': King's College London)H-Index: 6
Last. Deepak Cyril D'Souza (Yale University)H-Index: 35
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Abstract Prospective epidemiological studies have consistently demonstrated that cannabis use is associated with an increased subsequent risk of both psychotic symptoms and schizophrenia-like psychoses. Early onset of use, daily use of high-potency cannabis, and synthetic cannabinoids carry the greatest risk. The risk-increasing effects are not explained by shared genetic predisposition between schizophrenia and cannabis use. Experimental studies in healthy humans show that cannabis and its acti...
31 CitationsSource
#1Lauren E. Gibson (TU: Temple University)H-Index: 6
#2Lauren B. Alloy (TU: Temple University)H-Index: 68
Last. Lauren M. Ellman (TU: Temple University)H-Index: 17
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Abstract Traumatic life events have been robustly associated with various psychosis outcomes, including increased risk of psychotic disorders, the prodrome of psychosis, and dimensional measures of psychotic symptoms, such as attenuated positive psychotic symptoms. However, trauma exposure has been linked to various mental disorders; therefore, the specificity of trauma exposure to psychosis remains unclear. This review focuses on two understudied areas of the trauma and psychosis literature: 1)...
40 CitationsSource
#1Tabea Schoeler ('KCL': King's College London)H-Index: 10
#2Natalia Petros ('KCL': King's College London)H-Index: 4
Last. Sagnik Bhattacharyya ('KCL': King's College London)H-Index: 33
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Importance Cannabis use after first-episode psychosis is associated with poor outcomes, but the causal nature of this association is unclear. Objective To examine the precise nature of the association between continued cannabis use after the onset of psychosis and risk of relapse of psychosis. Design, Setting, and Participants This prospective cohort study followed up for at least 2 years after the onset of psychosis 220 patients who presented to psychiatric services in South London, England, fr...
27 CitationsSource
#1Robin M. Murrayand ('KCL': King's College London)H-Index: 149
#2Harriet Quigley ('KCL': King's College London)H-Index: 2
Last. M. Di Forti ('KCL': King's College London)H-Index: 36
view all 5 authors...
Epidemiological evidence demonstrates that cannabis use is associated with an increased risk of psychotic outcomes, and confirms a dose-response relationship between the level of use and the risk of later psychosis. High-potency cannabis and synthetic cannabinoids carry the greatest risk. Experimental administration of tetrahydrocannabinol, the active ingredient of cannabis, induces transient psychosis in normal subjects, but this effect can be ameliorated by co-administration of cannabidiol. Th...
61 CitationsSource
#1Justin Davis (Deakin University)H-Index: 5
#2Harris A. Eyre (Deakin University)H-Index: 14
Last. Michael BerkH-Index: 93
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Schizophrenia risk has often been conceptualized using a model which requires two hits in order to generate the clinical phenotype—the first as an early priming in a genetically predisposed individual and the second a likely environmental insult. The aim of this paper was to review the literature and reformulate this binary risk-vulnerability model. We sourced the data for this narrative review from the electronic database PUBMED. Our search terms were not limited by language or date of publicat...
98 CitationsSource
Background People born in densely populated areas have a higher risk of developing schizophrenia, bipolar disorder and autism. Aims The purpose of this study was to investigate whether urban–rural differences in place of birth influence a broad range of mental disorders. Method Population-based cohort study of everyone born in Denmark between 1955 and 2006 ( n = 2 894 640). Main outcome measures were incidence rate ratios for five levels of urbanisation and summary estimates contrasting birth in...
31 CitationsSource
#1Joseph M. Boden (University of Otago)H-Index: 41
#2S. van Stockum (Wellington Management Company)H-Index: 1
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BACKGROUND: There has been considerable recent interest in possible causal linkages between exposure to bullying victimization and later psychotic symptomatology. Prior research in this area has had several limitations which make it difficult to ascertain causality, and to determine the extent to which these effects extend beyond adolescence. METHOD: Data were obtained from the Christchurch Health and Development Study, a 35-year study of a longitudinal birth cohort. This investigation used gene...
15 CitationsSource
#1Jana JanoutováH-Index: 4
#2Janácková PH-Index: 1
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Abstract Schizophrenia is a severe mental disorder that affects approximately one percent of the general population. The pathogenesis of schizophrenia is influenced by many risk factors, both environmental and genetic. The environmental factors include the date of birth, place of birth and seasonal effects, infectious diseases, complications during pregnancy and delivery, substance abuse and stress. At the present time, in addition to environmental factors, genetic factors are assumed to play a ...
15 Citations
Objective:The authors sought to clarify the relationship between IQ and subsequent risk for schizophrenia.Method:IQ was assessed at ages 18–20 in 1,204,983 Swedish males born between 1951 and 1975. Schizophrenia was assessed by hospital diagnosis through 2010. Cox proportional hazards models were used to investigate future risk for schizophrenia in individuals as a function of their IQ score, and then stratified models using pairs of relatives were used to adjust for familial cluster. Finally, r...
49 CitationsSource
#1M. Di Forti ('KCL': King's College London)H-Index: 36
#2Arianna Marconi ('KCL': King's College London)H-Index: 4
Last. Robin M. Murrayand ('KCL': King's College London)H-Index: 149
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Summary Background The risk of individuals having adverse effects from drug use (eg, alcohol) generally depends on the frequency of use and potency of the drug used. We aimed to investigate how frequent use of skunk-like (high-potency) cannabis in south London affected the association between cannabis and psychotic disorders. Methods We applied adjusted logistic regression models to data from patients aged 18–65 years presenting to South London and Maudsley NHS Foundation Trust with first-episod...
221 CitationsSource
Cited By2
Newest
#1Toni Myllyaho (University of Oulu)H-Index: 1
#2Virva Siira (University of Oulu)H-Index: 3
Last. Sami Räsänen (OUH: Oulu University Hospital)H-Index: 5
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Abstract Objective The aim of this study was to examine the association of family functioning to psychiatric disorders of adoptees with and without genetic vulnerability to schizophrenia. Methods The data is based on the Finnish Adoptive Family Study of Schizophrenia. The study sample consisted of 346 adoptive families, of which 175 adoptees had high (HR) and 171 low (LR) genetic risk for schizophrenia. DSM-III-R was used for diagnostic criteria. Family functioning was assessed using the Global ...
1 CitationsSource
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