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What are the psychological effects of using synthetic cannabinoids? A systematic review:

Published on Mar 1, 2019in Journal of Psychopharmacology4.221
· DOI :10.1177/0269881119826592
Hina Akram1
Estimated H-index: 1
(UCL: University College London),
Claire Mokrysz10
Estimated H-index: 10
(UCL: University College London),
H. Valerie Curran43
Estimated H-index: 43
(UCL: University College London)
Abstract
Background:Synthetic cannabinoids are, typically, full agonists at the cannabinoid CB1 receptor, and therefore considerably more potent than natural cannabis and may have correspondingly more serio...
  • References (51)
  • Citations (2)
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References51
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#1Nena Bowman (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2E. Martin Caravati (University of Utah Hospital)H-Index: 28
Last. Barbara Insley Crouch (UofU: University of Utah)H-Index: 11
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AbstractBackground: We describe the clinical course of one industrial technician occupationally exposed to nickel carbonyl (NiC).Case report: A 50-year-old male industrial technician presented with complaints of nausea, myalgia, and cough to a local clinic after suspected occupational exposure to nickel carbonyl. He has no history of lung disease or smoking. His initial urine nickel concentration was 692 ug/L. He had infiltrates on the initial chest X-ray (CXR) and an oxygen saturation (O2) of 9...
1 CitationsSource
#1Eef L. Theunissen (UM: Maastricht University)H-Index: 21
#2Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
Last. Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
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Background and Purpose Synthetic cannabinoids (often sold as Spice or K2) have become a very popular alternative to cannabis due to their easy access and portrayed safety. Controlled studies on the behavioural effects of synthetic cannabinoids are currently lacking, which hampers risk assessments of these compounds. Experimental Approach This is a first attempt to assess the influence of a synthetic cannabinoid, JWH-018, on neurocognition and subjective experience in humans after controlled admi...
10 CitationsSource
#1Szilvia Kassai (ELTE: Eötvös Loránd University)H-Index: 2
#2Judit Nóra Pintér (University of Szeged)H-Index: 1
Last. V. Anna Gyarmathy (Semmelweis University)H-Index: 17
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Background New psychoactive substances (NPS) have been increasingly consumed by people who use drugs in recent years, which pose a new challenge for treatment services. One of the largest groups of NPS is synthetic cannabinoids (SCs), which are intended as a replacement to cannabis. While there is an increasing body of research on the motivation and the effects associated with SC use, little is known about the subjective interpretation of SC use by the people who use drugs themselves. The aim of...
7 CitationsSource
#1Aviv Weinstein (Ariel University)H-Index: 26
#2Paola RoscaH-Index: 1
Last. Edythe D. London (UCLA: University of California, Los Angeles)H-Index: 79
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As part of an increasing worldwide use of designer drugs, recent use of compounds containing cathinones and synthetic cannabinoids is especially prevalent. Here we reviewed current literature on the prevalence, epidemiology, bio-behavioral effects and detection of these compounds. Gender differences and clinical effects will also be examined. Chronic use of synthetic cathinone compounds can have major effects on the central nervous system, and can induce acute psychosis, hypomania, paranoid idea...
33 CitationsSource
#1Marc W. Manseau (NYU: New York University)H-Index: 7
#2Amit Rajparia (NYU: New York University)H-Index: 4
Last. Crystal Fuller Lewis (NYU: New York University)H-Index: 6
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ABSTRACTBackground: Increasing reports of synthetic cannabinoid (SC)-related adverse events have largely comprised case reports and analyses of calls to poison control centers. Existing studies have also mostly involved white male populations. Objectives: The purpose of this study is to systematically describe clinical characteristics of SC use in a relatively large, diverse, urban sample presenting to a psychiatric emergency setting. Methods: SC users (n = 110) were identified by reviewing char...
13 CitationsSource
#1Heather B. ClaytonH-Index: 8
#2Richard LowryH-Index: 50
Last. Althea M. Grant (CDC: Centers for Disease Control and Prevention)H-Index: 17
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BACKGROUND AND OBJECTIVES: Data are limited on the behavioral risk correlates of synthetic cannabinoid use. The purpose of this study was to compare the behavioral risk correlates of synthetic cannabinoid use with those among marijuana users. METHODS: Data from the 2015 Youth Risk Behavior Survey, a cross-sectional survey conducted in a nationally representative sample of students in grades 9 through 12 ( N = 15 624), were used to examine the association between self-reported type of marijuana u...
11 CitationsSource
#1Marie Claire Van Hout (WIT: Waterford Institute of Technology)H-Index: 16
#2Evelyn Hearne (WIT: Waterford Institute of Technology)H-Index: 6
Emergence of synthetic cannabinoids (SCBs) in herbal smoking mixtures is a public health concern. New SCB’s such as 5f-AKB48 and 5F-PB-22 have been detected in French seizures and in sudden death post mortems in the US. The aim was to describe development of dependence on herbal smoking mixtures containing the SCB’s, 5f-AKB48 and 5F-PB-22 and subsequent withdrawal syndromes. Dependent users of herbal smoking mixtures known to contain the SCB’s 5f-AKB48 and 5F-PB-22 with an average Severity of De...
15 CitationsSource
#1K Cohen (ELTE: Eötvös Loránd University)H-Index: 1
#2Máté Kapitány-Fövény (Semmelweis University)H-Index: 9
Last. Aviv WeinsteinH-Index: 26
view all 7 authors...
Background and aims There is a growing use of novel psychoactive substances (NPSs) including synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis but the new synthetic cannabinoids are more potent and dangerous and their use has resulted in various adverse effects. The purpose of the study was to assess whether persistent use of synthetic cannabinoids is associating with impairments of executive function in chronic users.
17 CitationsSource
#1D Souza DcH-Index: 1
#2Rajiv RadhakrishnanH-Index: 14
Last. Mohini RanganathanH-Index: 24
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#1Stella WelterH-Index: 1
#2Caroline LückeH-Index: 5
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Background: Consumption of natural cannabis (NC) and synthetic cannabinoids (SCs) has been associated with psychotic disorders. We compared the prevalence of use,
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#1Dino Luethi (University of Basel)H-Index: 7
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Psychoactive substances with chemical structures or pharmacological profiles that are similar to traditional drugs of abuse continue to emerge on the recreational drug market. Internet vendors may at least temporarily sell these so-called designer drugs without adhering to legal statutes or facing legal consequences. Overall, the mechanism of action and adverse effects of designer drugs are similar to traditional drugs of abuse. Stimulants, such as amphetamines and cathinones, primarily interact...
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#1Erwin Krediet (LUMC: Leiden University Medical Center)
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There are few medications with demonstrated efficacy for the treatment of posttraumatic stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy as a first line treatment for PTSD. Yet, even after psychotherapy, PTSD often remains a chronic illness, with high rates of psychiatric and medical comorbidity. Meanwhile, the search and development of drugs with new mechanisms of action has stalled. Therefore, there is an urgent need to explore not just novel compounds, ...
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#1Caroline M Kopruszinski (UA: University of Arizona)
#2Edita Navratilova (UA: University of Arizona)H-Index: 21
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AimEvaluation of cannabinoid receptor agonists in a preclinical model of medication overuse headache.MethodsFemale Sprague Dawley rats received graded intraperitoneal doses of WIN55,212-2 or Δ-9-te...
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#1Laura OrsoliniH-Index: 14
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The critical spread and dissemination of novel psychoactive substances (NPS), particularly among the most vulnerable youngsters, may pose a further concern about the psychotic trajectories related to the intake of new synthetic drugs. The psychopathological pattern of the “new psychoses” appears to be extremely different from the classical presentation. Therefore, clinicians need more data on these new synthetic psychoses and recommendations on how to manage them. The present mini-review aims at...
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