Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis
Abstract
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition reduces plasma concentrations of low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)]. Atherogenic lipoprotein levels have been linked with calcific aortic valve stenosis (CAVS). Our objectives were to determine the association between variants in PCSK9 and lipoprotein-lipid levels, coronary artery disease (CAD) and CAVS, and...
Paper Details
Title
Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis
Published Date
Mar 1, 2019
Journal
Pages
560458
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