Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Abstract
Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by hyperglycemia due to progressive loss of pancreatic beta cells. Immune-mediated beta cell destruction drives the disease, but whether beta cells actively participate in the pathogenesis remains unclear. Here, we show that during the natural history of T1D in humans and the non-obese diabetic (NOD) mouse model, a subset of beta cells acquires a senescence-associated...
Paper Details
Title
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Published Date
May 1, 2019
Journal
Volume
29
Issue
5
Pages
1045 - 1060.e10
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Notes
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