CD4⁺T help promotes influenza virus-specific CD8⁺T cell memory by limiting metabolic dysfunction

Significance Promoting effective CD8 + T cell memory is a primary goal of T cell-based vaccination and immunotherapy strategies. While it is well established that CD4 + T cell help is required for enduring CD8 + T cell memory, how such help contributes to establishing optimal CD8 + T cell memory generation and persistence remains unclear. In this study, we demonstrate that CD4 + help at the time of priming ensures that memory CD8 + T cells are...