P054 IRF-1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes

Career situation of first and presenting author

Young investigator.

Introduction

Rheumatoid arthritis (RA) is an autoimmune disease, which is characterized by persistent, synovial inflammation. Major drivers of synovial inflammation are cytokines and chemokines. Among them TNF activates fibroblast-like synoviocytes (FLS), which leads to the production of inflammatory mediators. The pathways and transcription factors that...