A genome-wide screen for ER autophagy highlights key roles of mitochondrial metabolism and ER-resident UFMylation
Abstract
Summary null Selective degradation of organelles via autophagy is critical for cellular differentiation, homeostasis, and organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but is poorly understood beyond a few specialized autophagosomal receptors and remodelers. Using an ER-phagy reporter and genome-wide CRISPRi screening, we identified 200 high-confidence factors involved in human ER-phagy. We mechanistically...
Paper Details
Title
A genome-wide screen for ER autophagy highlights key roles of mitochondrial metabolism and ER-resident UFMylation
Published Date
Feb 25, 2019
Journal
Pages
561001
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