Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on testosterone, sperm and prostate parameters

Published on May 1, 2019in Journal of Ethnopharmacology 3.41
· DOI :10.1016/j.jep.2019.02.033
Heitor O. Santos2
Estimated H-index: 2
(UFU: Federal University of Uberlandia),
Scott L. Howell , Filipe J. Teixeira1
Estimated H-index: 1
(University of Lisbon)
Abstract Ethno-pharmacological relevance Phytotherapeutic approaches have been widely proposed to improve male health. Despite the well-touted effects of tribulus (Tribulus terrestris L) on men's health, an optimal phytotherapy remains an elusive challenge. Aim of the review We sought to critically analyze the evidence in the phytotherapic literature beyond the effects of tribulus on testosterone (T) concentration and sperm analysis to also include indications for prostate health. Materials and methods A focused literature search was conducted to include studies published in Cochrane, Pubmed, and Web of Science databases between the years 2002 and 2018. Results The use of tribulus and maca ( Lepidium meyenii Walp, Brassicaceae) were not scientifically supported to improve serum T levels in men. Moderate evidence supports the use of long Jack ( Eurycoma longifolia Jack, Simaroubaceae), mucuna ( Mucuna pruriens (L.) DC., Fabaceae), ashwagandha ( Withania somnifera (L.) Dunal, Solanaceae), fenugreek ( Trigonella foenum-graceum L., Fabaceae), and black seeds ( Nigella sativa L., Ranunculaceae) to increase total T and improve seminal parameters. Data suggests an increase in total T with the use of 5000 mg/d of powdered mucuna seed and ashwagandha root (151 and 143 ng/dL, respectively) over a 12-week period in patients with oligozoospermia. The use of mucuna was supported for patients with oligozoospermia to improve sperm parameters, with an increase of 83.3 million/mL observed after use of 5000 mg/d of powdered mucuna seed over a 12-week period. Evidence supporting the use of saw palmetto ( Serenoa repens , (W.Bartram) Small, Arecaceae) to improve prostate health remains equivocal; whereas, evidence supporting the use of Pygeum africanum Hook.f., Rosaceae, Urtica dioica L., Urticaceae, beta-sitosterols, pollen extract, onion, garlic, and tomato, appears favorable and promising. Conclusion Scientific evidence supports the use of mucuna and ashwagandha as phytotherapics for improving serum T concentrations and semen parameters. Despite inconclusive evidence for use of tribulus as a T booster, it may provide advantageous effects on sperm parameters in men with idiopathic infertility. Nutraceutical strategies and some phytotherapics may also be effective to promote prostate health. Popular foodstuffs (onion, garlic, and tomato), nutraceutical agents (pollen extract and beta-sitosterols), and herbal medicines ( Pygeum africanum and Urtica dioica ) are rational approaches.
  • References (159)
  • Citations (0)
Published on Apr 1, 2019in Nutrition 3.59
Paula Helena Dayan1
Estimated H-index: 1
(USP: University of São Paulo),
Gary A. Sforzo6
Estimated H-index: 6
(Ithaca College)
+ 2 AuthorsAntonio Herbert Lancha30
Estimated H-index: 30
(USP: University of São Paulo)
Abstract Although current guidelines for obesity treatment endorse lifestyle modifications to achieve weight loss, energy-restricted diets are still the most commonly used method for the management of overweight. Diet restriction, however, not only is ineffective in promoting long-term weight loss but also may have more costs than benefits, predisposing the individual to fat regain. Several physiological and psychological mechanisms protect the body against starvation and explain how food restri...
Published on Apr 1, 2019in Clinical Nutrition 6.40
Nagisa Mori2
Estimated H-index: 2
Taichi Shimazu36
Estimated H-index: 36
+ 11 AuthorsRibeka Takachi18
Estimated H-index: 18
(Nara Women's University)
Summary Background & aims Cruciferous vegetables contain isothiocyanates, which effectively reduce inflammation and oxidative stress related to chronic diseases, inhibit the bioactivation of procarcinogens, and enhance the excretion of carcinogens. However, at present, no large cohort studies have investigated the effect of cruciferous vegetable on mortality. We aimed to examine the association between cruciferous vegetable intake and all-cause mortality, namely cancer, heart disease, cerebrovas...
Published on Feb 1, 2019in Primary Care Diabetes 2.01
Ehsan Shabani1
Estimated H-index: 1
Korosh Sayemiri1
Estimated H-index: 1
Mohammadtaghi Mohammadpour1
Estimated H-index: 1
PURPOSE: Several studies have been published about the effect of garlic on lipid profile and blood glucose in diabetic patients. Which, the results mostly contradict with each other. This study aimed to investigate the effect of garlic on lipid profile and serum glucose levels in diabetic patients using a systematic review and meta-analysis. METHODS: This study was a systematic review and meta-analysis of articles published between 1988 and 2016. For this purpose, two independent researchers sea...
Published on Feb 1, 2019in Complementary Therapies in Medicine 1.98
Sima Sanagoo1
Estimated H-index: 1
(Tabriz University of Medical Sciences),
Behnaz Sadeghzadeh Oskouei1
Estimated H-index: 1
(Tabriz University of Medical Sciences)
+ 3 AuthorsAzizeh Farshbaf-Khalili5
Estimated H-index: 5
(Tabriz University of Medical Sciences)
Abstract Background and objective(S) Tribulus terrestris L. is an herbal plant that has long been used as sex stimulant and to treat male infertility. This systematic review collected the clinical trials and/or quasi-experimental studies on the effect of T. terrestris on sperm parameters in idiopathic male infertility. Materials and methods To search the related articles, Cochrane Library, EMBASE, ProQuest,, WHO, Google Scholar, MEDLINE via Pubmed, Web of Science, SID, Magiran,...
Published on Jan 2, 2019in The Aging Male 2.50
Aldo E. Calogero33
Estimated H-index: 33
(University of Catania),
Giovanni Burgio3
Estimated H-index: 3
(University of Catania)
+ 2 AuthorsSandro La Vignera22
Estimated H-index: 22
(University of Catania)
AbstractBenign prostatic hyperplasia (BPH) is very common in aging men and causes lower urinary tract symptoms (LUTS), which decrease health-related quality of life. A number of evidence suggests that other than ageing, modifiable factors, such as increasing prostate volume, obesity, diet, dyslipidemia, hormonal imbalance, hypertension, metabolic syndrome, alcohol, and smoking, also contribute to the development of BPH and/or LUTS. More recently, erectile dysfunction (ED) has been linked to LUTS...
Published on Dec 1, 2018in World Journal of Surgical Oncology 1.97
Ashley B. Ward2
Estimated H-index: 2
(Morehouse School of Medicine),
Hina Mir9
Estimated H-index: 9
(Morehouse School of Medicine)
+ 3 AuthorsShailesh Singh25
Estimated H-index: 25
(Morehouse School of Medicine)
Despite recent advances in diagnosis and treatment, prostate cancer (PCa) remains the leading cause of cancer-related deaths in men. Current treatments offered in the clinics are often toxic and have severe side effects. Hence, to treat and manage PCa, new agents with fewer side effects or having potential to reduce side effects of conventional therapy are needed. In this study, we show anti-cancer effects of quercetin, an abundant bioflavonoid commonly used to treat prostatitis, and defined que...
Published on Nov 1, 2018in The American Journal of Clinical Nutrition 6.57
Albert Salas-Huetos7
Estimated H-index: 7
(ISCIII: Instituto de Salud Carlos III),
Rocío Moraleda1
Estimated H-index: 1
+ 4 AuthorsMònica Bulló44
Estimated H-index: 44
(ISCIII: Instituto de Salud Carlos III)
Published on Oct 22, 2018
Saleem Ali Banihani7
Estimated H-index: 7
Enhancing and protecting testosterone production is one target for many scientists because of its crucial role as a primary sex hormone in males. Several in vivo trials have utilized different dietary supplements and medicinal plants to enhance testosterone production in males. Since 1991, various in-vivo, as well as basic research studies, have discovered a link between ginger (Zingiber officinale) and testosterone. However, such a link has not yet been collectively reviewed. This review system...
Published on Oct 10, 2018in PLOS Medicine
Fumiaki Imamura27
Estimated H-index: 27
(University of Cambridge),
Amanda M. Fretts16
Estimated H-index: 16
(UW: University of Washington)
+ 46 AuthorsKerry Wong1
Estimated H-index: 1
(Cancer Council Victoria)
Background We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D). Methods and findings Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardis...
Published on Oct 7, 2018in Journal of HerbMed Pharmacology
Hadis Musavi1
Estimated H-index: 1
Malihe Tabnak1
Estimated H-index: 1
+ 3 AuthorsMojtaba Abbasi1
Estimated H-index: 1
Introduction: Fertility in men mainly depends on the number, quality, motility, and morphology of the sperms, and disruption of each of these factors leads to infertility. A large number of couples suffer from infertility problems. Among the various therapies, medicinal herbs are used in many countries to treat male infertility. Current systematic review was conducted to study the effects of garlic on male fertility.Methods: The information of this systematic review was collected by searching th...
Cited By0