Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches
Abstract
Type 2 lymphocytes promote both physiologic tissue remodeling and allergic pathology, yet their physical tissue niches are poorly described. Here, we used quantitative imaging to define the tissue niches of group 2 innate lymphoid cells (ILC2s), which are critical instigators of type 2 immunity. We identified a dominant adventitial niche around lung bronchi and larger vessels in multiple tissues, where ILC2s localized with subsets of dendritic...
Paper Details
Title
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches
Published Date
Mar 1, 2019
Journal
Volume
50
Issue
3
Pages
707 - 722.e6
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