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Mesenteric adipose tissue B lymphocytes promote local and hepatic inflammation in non‐alcoholic fatty liver disease mice

Published on May 1, 2019in Journal of Cellular and Molecular Medicine 4.30
· DOI :10.1111/jcmm.14232
Zhe Wu2
Estimated H-index: 2
(PKU: Peking University),
Jun Xu1
Estimated H-index: 1
(PKU: Peking University)
+ 7 AuthorsYulan Liu7
Estimated H-index: 7
(PKU: Peking University)
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References38
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Published on Aug 1, 2018in Free Radical Biology and Medicine 6.02
Stefania Bruzzì5
Estimated H-index: 5
,
Salvatore Sutti12
Estimated H-index: 12
+ 9 AuthorsMaurizio Parola48
Estimated H-index: 48
(UNITO: University of Turin)
Abstract Recent evidence implicates adaptive immunity as a key player in the mechanisms supporting hepatic inflammation during the progression of nonalcoholic fatty liver disease (NAFLD). In these settings, patients with NAFLD often show an increase in the circulating levels of antibodies against oxidative stress-derived epitopes (OSE). Nonetheless, the actual role of humoral immunity in NAFLD is still unclear. This study investigates the contribution of B-lymphocytes to NAFLD evolution. B-lymph...
1 Citations Source Cite
Published on Apr 1, 2018in Diabetologia 6.02
Lily Boutens7
Estimated H-index: 7
(WUR: Wageningen University and Research Centre),
Guido Hooiveld37
Estimated H-index: 37
(WUR: Wageningen University and Research Centre)
+ 3 AuthorsRinke Stienstra29
Estimated H-index: 29
(WUR: Wageningen University and Research Centre)
Aims/hypothesis Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance, yet changes in their intracellular energy metabolism are currently unknown. We therefore set out to study metabolic signatures of adipose tissue macrophages (ATMs) in lean and obese conditions.
21 Citations Source Cite
Published on Mar 1, 2017in Journal of Clinical Investigation 13.25
Wei Ying12
Estimated H-index: 12
(UCSD: University of California, San Diego),
Joshua Wollam7
Estimated H-index: 7
(UCSD: University of California, San Diego)
+ 7 AuthorsJerrold M. Olefsky106
Estimated H-index: 106
(UCSD: University of California, San Diego)
28 Citations Source Cite
Published on Jan 3, 2017in Journal of Clinical Investigation 13.25
Tracey McLaughlin40
Estimated H-index: 40
,
Shelley E. Ackerman1
Estimated H-index: 1
+ 1 AuthorsEdgar G. Engleman79
Estimated H-index: 79
Abstract Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy, hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a critical role in the development of obesity-associated insulin resistance (IR). Cells of both the innate and adaptive immune system residing in adipose tissues, as well as in the intestine, participate in this process. Thus, M1 macrophages, IFN-γ-secreting Th1 cells, CD8+ T cells, and B cells promote IR, in part...
38 Citations Source Cite
Published on Sep 1, 2016in Journal of Hepatology 15.04
Amon Asgharpour5
Estimated H-index: 5
(VCU: Virginia Commonwealth University),
Sophie C. Cazanave24
Estimated H-index: 24
(VCU: Virginia Commonwealth University)
+ 15 AuthorsFaridoddin Mirshahi15
Estimated H-index: 15
(VCU: Virginia Commonwealth University)
Background & Aims The lack of a preclinical model of progressive non-alcoholic steatohepatitis (NASH) that recapitulates human disease is a barrier to therapeutic development. Methods A stable isogenic cross between C57BL/6J (B6) and 129S1/SvImJ (S129) mice were fed a high fat diet with ad libitum consumption of glucose and fructose in physiologically relevant concentrations and compared to mice fed a chow diet and also to both parent strains. Results Following initiation of the obesogenic diet,...
82 Citations Source Cite
Published on Aug 1, 2016in Metabolism-clinical and Experimental 5.96
Elena Buzzetti4
Estimated H-index: 4
(Royal Free Hospital),
Massimo Pinzani77
Estimated H-index: 77
(Royal Free Hospital),
Emmanuel Tsochatzis29
Estimated H-index: 29
(Royal Free Hospital)
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. Despite its high prevalence, only a small minority of affected patients develops inflammation and subsequently fibrosis and chronic liver disease, while most of them only exhibit simple steatosis. In this context, the full understanding of the mechanisms underlying the development of NAFLD and non-alcoholic steatohepatitis (NASH) is of extreme impor...
282 Citations Source Cite
Published on Jul 1, 2016in Journal of Digestive Diseases 1.62
Feng Zhang4
Estimated H-index: 4
(PKU: Peking University),
Wei Wei Jiang1
Estimated H-index: 1
(PKU: Peking University)
+ 5 AuthorsYu Lan Liu2
Estimated H-index: 2
(PKU: Peking University)
To investigate the alterations and functions of intrahepatic B (IHB) cells in non-alcoholic fatty liver disease (NAFLD) model induced by high-fat diet (HFD).C57BL/6 J mice were fed with HFD for 16 weeks to induce NAFLD. Flow cytometry was used to analyze lymphocytes from liver, spleen and peripheral blood mononuclear cells (PBMC). Real-time polymerase chain reaction and immunofluorescence stain were applied to investigate cytokine expression in the intrahepatic lymphocytes and IHB cells. CD4(+) ...
2 Citations Source Cite
Published on May 24, 2016in Journal of Digestive Diseases 1.62
Feng Zhang4
Estimated H-index: 4
(PKU: Peking University),
Weiwei Jiang3
Estimated H-index: 3
(PKU: Peking University)
+ 5 AuthorsYu Lan Liu2
Estimated H-index: 2
(PKU: Peking University)
Aims To investigate the alterations and functions of B cells, especially the intrahepatic B (IHB) cells in high-fat diet (HFD) induced non-alcoholic fatty liver disease (NAFLD). Methods C57BL/6 J mice were induced NAFLD using 16-week HFD. Flow cytometry was used to analyze B cells and T cells in different tissues and co-culture system. Real-time PCR and immunofluorescence staining assays were applied to investigate cytokines expressions in livers, intrahepatic lymphocytes and IHB cells. CD4+ int...
1 Citations Source Cite
Published on Mar 1, 2016in Journal of Gastroenterology and Hepatology 3.48
Ying Hu4
Estimated H-index: 4
(PKU: Peking University),
Henghui Zhang10
Estimated H-index: 10
(PKU: Peking University)
+ 5 AuthorsLiu Y7
Estimated H-index: 7
(PKU: Peking University)
Background and Aim Most studies focus on gut-derived factors like microbiota and its products and how they contribute to non-alcoholic fatty liver disease (NAFLD) progression. This study investigated whether the gut-derived lymphocytes could migrate to the liver and induce liver injury in NAFLD. Methods A high-fat diet induced an NAFLD mouse model, and lymphocytes were labeled with 1,1-dioctadecyl-3,3,3,3 tetramethylindotricarbocyanine iodide and carboxy-fluorescein succinimidyl ester, respectiv...
9 Citations Source Cite
Published on Dec 1, 2015in Medicine 2.03
Su Jong Yu19
Estimated H-index: 19
,
Won-Seog Kim69
Estimated H-index: 69
+ 8 AuthorsYoon Jun Kim36
Estimated H-index: 36
Nonalcoholic fatty liver disease (NAFLD) is associated with visceral obesity. However, the association between visceral adipose tissue (VAT) area and fibrosis in NAFLD patients has not been completely established. This study was aimed to determine the relationship between the computed tomography-measured VAT area and significant fibrosis in NAFLD patients. A total of 324 NAFLD patients and 132 controls were evaluated by liver biopsy. NAFLD was diagnosed based on histological examinations and alc...
24 Citations Source Cite
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