Senolytics and senostatics as adjuvant tumour therapy
Abstract
Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline. In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it blocks tumour growth. However, this is frequently incomplete, and tumour cells that recover from senescence may gain a more stem-like state with increased proliferative potential. This might be exaggerated by the induction of senescence in the surrounding...
Paper Details
Title
Senolytics and senostatics as adjuvant tumour therapy
Published Date
Mar 1, 2019
Journal
Volume
41
Pages
683 - 692
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Notes
History