Original paper
Mechanistic investigation of anthocyanidin derivatives as α-glucosidase inhibitors
Abstract
Eight anthocyanidin derivatives (1-8) were evaluated as potential inhibitors of the catalysis of α-glucosidase. Among them, compounds 4 and 8 had the highest levels of inhibitory activity at 100 μM (IC50 values of 14.4 ± 0.1 and 29.7 ± 1.2 μM) and acted in a dose-dependent manner. Enzyme kinetic analysis further revealed that these inhibitors interacted with α-glucosidase in a mixed noncompetitive mode. Moreover, fluorescence quenching studies...
Paper Details
Title
Mechanistic investigation of anthocyanidin derivatives as α-glucosidase inhibitors
Published Date
Jun 1, 2019
Journal
Volume
87
Pages
803 - 809
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Notes
History