Higher urate in LRRK2 mutation carriers resistant to Parkinson disease
Abstract
LRRK2 mutations, the most common genetic cause of Parkinson disease (PD), display incomplete penetrance, indicating the importance of other genetic and environmental influences on disease pathogenesis in LRRK2 mutation carriers. The present study investigates whether urate, an antioxidant, Nrf2 activator, and inverse risk factor for idiopathic PD, is one such candidate biomarker of PD risk modulation in pathogenic LRRK2 mutation carriers.Banked...
Paper Details
Title
Higher urate in LRRK2 mutation carriers resistant to Parkinson disease
Published Date
Mar 3, 2019
Journal
Volume
85
Issue
4
Pages
593 - 599
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