A commonSNP in theUNGgene decreases ovarian cancer risk inBRCA 2mutation carriers
Abstract
Single nucleotide polymorphisms (SNPs) in DNA glycosylase genes involved in the base excision repair (BER) pathway can modify breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We previously found that SNP rs34259 in the uracil-DNA glycosylase gene (UNG) might decrease ovarian cancer risk in BRCA2 mutation carriers. In the present study, we validated this finding in a larger series of familial breast and ovarian cancer patients...
Paper Details
Title
A commonSNP in theUNGgene decreases ovarian cancer risk inBRCA 2mutation carriers
Published Date
Mar 1, 2019
Journal
Volume
13
Issue
5
Pages
1110 - 1120
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