Original paper
Chronic exercise mitigates disease mechanisms and improves muscle function in myotonic dystrophy type 1 mice
Abstract
Myotonic dystrophy type 1 (DM1), the second most common muscular dystrophy and most prevalent adult form of muscular dystrophy, is characterized by muscle weakness, wasting and myotonia. A microsatellite repeat expansion mutation results in RNA toxicity and dysregulation of mRNA processing, which are the primary downstream causes of the disorder. Recent studies with DM1 participants demonstrate that exercise is safe, enjoyable and elicits...
Paper Details
Title
Chronic exercise mitigates disease mechanisms and improves muscle function in myotonic dystrophy type 1 mice
Published Date
Jan 30, 2019
Journal
Volume
597
Issue
5
Pages
1361 - 1381
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Notes
History