Original paper
Potent and highly selective dual‐targeting monoamine oxidase‐B inhibitors: Fluorinated chalcones of morpholine versus imidazole
Abstract
Two series of fluorinated chalcones containing morpholine and imidazole‐based compounds ( f1–f8 ) were synthesized and evaluated for recombinant human monoamine oxidase (MAO)‐A and ‐B as well as acetylcholinesterase inhibitory activities. Our results indicate that morpholine containing chalcones are highly selective MAO‐B inhibitors having reversibility properties. All the imidazole‐based fluorinated chalcones showed weak MAO inhibitions in both...
Paper Details
Title
Potent and highly selective dual‐targeting monoamine oxidase‐B inhibitors: Fluorinated chalcones of morpholine versus imidazole
Published Date
Jan 21, 2019
Journal
Volume
352
Issue
4
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Notes
History