Circulating Spexin Decreased and Negatively Correlated with Systemic Insulin Sensitivity and Pancreatic β Cell Function in Obese Children

Published on Jan 1, 2019in Annals of Nutrition and Metabolism3.051
· DOI :10.1159/000496459
Ting Chen2
Estimated H-index: 2
Fengyun Wang2
Estimated H-index: 2
+ 6 AuthorsMiao Hou2
Estimated H-index: 2
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1 Author (三奈 末松)
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Cited By2
#1Maryam Behrooz (Tabriz University of Medical Sciences)
#2Elnaz Vaghef-Mehrabany (Tabriz University of Medical Sciences)H-Index: 5
Last. Alireza Ostadrahimi (Tabriz University of Medical Sciences)H-Index: 16
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Abstract Background and Aims Spexin (SPX) is a novel peptide recently discovered as an important regulatory adipokine in obesity and related metabolic diseases. The aim of the current study was to determine the potential role of Circulating levels of SPX in obese children and explore its relationships with obesity-related risk factors, and its potential role in preventing obesity. Methods 45 obese children and 45normal-weight children of similar age and sex, with mean age of 13.73(2.68) were rec...
#1Penghua Fang (Nanjing University of Chinese Medicine)H-Index: 2
#2Mei Yu (Nanjing University of Chinese Medicine)H-Index: 7
Last. Zhenwen Zhang (YZU: Yangzhou University)H-Index: 9
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Abstract Recent preclinical and clinical studies have indicated that the galanin peptide family may regulate glucose metabolism and alleviate insulin resistance, which diminishes the probability of type 2 diabetes mellitus. The galanin was discovered in 1983 as a gut-derived peptide hormone. Subsequently, galanin peptide family was found to exert a series of metabolic effects, including the regulation of gut motility, body weight and glucose metabolism. The galanin peptide family in modulating g...
1 CitationsSource
The Spexin gene is considered the most dysregulated in obese human fat. Limited data suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity. The aim of this case-control study was to compare fasting serum spexin concentrations between normal weight (NW) and overweight/obese (OB/OW) adolescent females and explore the relationship between circulating spexin and anthropometric, bone and fat mass, metabolic and hormonal parameters. Eighty post-...
#1Chor Hong Lim (Monash University Malaysia Campus)H-Index: 1
#2Megan You Min Lee (Monash University Malaysia Campus)H-Index: 1
Last. Ishwar S. Parhar (Monash University Malaysia Campus)H-Index: 34
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Spexin (SPX) is a novel neuropeptide, which was first identified in the human genome using bioinformatics. Since then, homologues of human SPX have been identified in mammalian and non-mammalian vertebrates; chicken, anole lizard, Nile tilapia, goldfish, zebrafish and fugu. The mature sequence of SPX, NWTPQAMLYLKGAQ, is evolutionally conserved across vertebrate species, with some variation in teleost species where Ala at position 13 is substituted by Thr. The presence of a RF-amide at the C-term...
#1Shuang-Yu Lv (Henan University)H-Index: 11
#2Yu-Chen Zhou (Henan University)H-Index: 1
Last. Yan-Dong Wang (Huada: Beijing University of Chemical Technology)H-Index: 7
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Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide. Spexin gene and protein is widely expressed in central nervous system and peripheral tissues in human, rodents, goldfish, ect. A few of physiological and pathological roles of spexin are gradually emerged recently. This article summarized the roles of spexin on feeding behavior, gastrointestinal motility, obesity, diabetes, energy metabolism, endocrine, mental diseases and cardiovascular function. Given the broad...