A chemical approach for global protein knockdown from mice to non-human primates
Abstract
Although conventional genetic modification approaches for protein knockdown work very successfully due to the increasing use of CRISPR/Cas9, effective techniques for achieving protein depletion in adult animals, especially in large animals such as non-human primates, are lacking. Here, we report a chemical approach based on PROTACs technology that efficiently and quickly knocks down FKBP12 (12-kDa FK506-binding) protein globally in vivo. Both...
Paper Details
Title
A chemical approach for global protein knockdown from mice to non-human primates
Published Date
Feb 5, 2019
Journal
Volume
5
Issue
1
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